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KMID : 0352720070310040175
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Journal of Ginseng Research
2007 Volume.31 No. 4 p.175 ~ p.180
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Effect of Korean Red Ginseng on Serum Soluble CD8 in HIV-1-Infected Patients
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Cho Young-Keol
Sung Heung-Sup
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Abstract
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To evaluate whether there is a relation between Korean red ginseng (KRG)-intake and the suppression of immune hyperactivation in HIV-1-infected patients, we measured serum soluble CD8 (sCD8) over 31-48 months in 168 patients. They were divided into four groups; HIV-1-infected control (n = 49), zidovudine (ZDV) group (n = 22), KRG group (n = 48), and combination of KRG and ZDV group (n = 49). In control, sCD8 and the ratio of sCD8/CD8+ T cells significantly increased by 33% (paired t-test, P ＜ 0.05) and 54% over 21 ± 13 months (P ＜ 0.001), respectively. In ZDV group, sCD8 decreased within first 6 months and then showed steady increase and the ratio also increased over 19 ± 10 months. In KRG group, sCD8 and the ratio of sCD/CD8+ T cells continuously decreased by 45% (P ＜ 0.01) and 19% over 19 ± 11 months (P ＜ 0.05), respectively. In combination group, sCD8 gradually decreased by 29% (P ＜ 0.01). There was a clear difference in the changes in serum sCD8 over time among 4 groups. There was no rebound phenomenon in KRG group as shown in ZDV group. These results suggest that KRG-intake suppresses immune hyperactivation state by HIV antigen itself in the HIV-infected patients
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KEYWORD
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HIV-1 infection, soluble CD8 antigen, Korean red ginseng, zidovudine
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